selective estrogen receptor degrader

Cat No.	Product Name	Synonyms	Targets
T9997	GLL 398		Estrogen Receptor/ERR
	GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.		Estrogen Receptor/ERR
T5118	Brilanestrant	GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Brilanestrant (GDC-0810) is a selective estrogen receptor degrader (IC50: 0.7 nM).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T39727	ERα degrader-2		ERK
	ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prev...		ERK
T15788	LSZ-102	LSZ102	Estrogen Receptor/ERR
	LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer.		Estrogen Receptor/ERR
T13674	Elacestrant	RAD1901	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T13675	Elacestrant dihydrochloride	RAD1901 dihydrochloride	Estrogen/progestogen Receptor
	Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively.		Estrogen/progestogen Receptor
T12832	Amcenestrant	SAR439859	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T39499	Rintodestrant	G1T48
	Rintodestrant (G1T48) is an orally active, non-steroidal, selective estrogen receptor degrader (SERD) that also functions as a CDK4/6 inhibitor.
T39118	AZD9496 maleate
	AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor...
T39368	GNE-149
	GNE-149 is an orally bioavailable compound that acts as a full antagonist of estrogen receptor α (ERα) with an IC50 of 0.053 nM. It is also classified as a selective estrogen receptor degrader (SERD). GNE-149 holds poten...
T70179	THIQ-40
	THIQ-40 is a novel potent erα antagonist and selective estrogen receptor degrader (serd), exhibiting good oral bioavailability, antitumor efficacy, and serd activity in vivo
T63922	ERα degrader 5
	ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.
T74856	ER degrader 4
	ER degrader 4, a selective and orally active compound, effectively degrades estrogen receptors and exhibits anti-tumor activity [1].
T11173	Elacestrant S enantiomer	RAD1901 S enantiomer	Others
	Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.		Others
T79382	ER degrader 6		Estrogen Receptor/ERR
	ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effe...		Estrogen Receptor/ERR
T63674	Imlunestrant
	Imlunestrant is a selective, orally active estrogen receptor degrader (SERD) that can be used in ER+ and HER2 breast cancer studies.
T74593	Taragarestrant meglumine
	Taragarestrant (D-0502) meglumine is a potent, orally active, and selective estrogen receptor degrader (SERD) demonstrating significant efficacy in ER+ breast cancer cell lines and xenograft models [1] [2].
T11173L	Elacestrant S enantiomer dihydrochloride	RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride	Others
	Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an l...		Others
T74415	Imlunestrant tosylate
	Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) exhibiting purely antagonistic properties. It effectively maintains inhibition of estrogen receptor (ER)-dependent...
T63165	LX-039
	LX-039 is a potent, selective, orally active estrogen receptor degrader (EC50: 2.99 nM) with antitumor effects.LX-039 has indole C-3 chloride atoms.LX-039 has good pharmacokinetic properties in mice, low clearance, high ...